醫(yī)學論文范文:三維適形放療同步TP方案化療治療局部晚期非小細胞肺癌

醫(yī)學論文范文:三維適形放療同步TP方案化療治療局部晚期非小細胞肺癌

【摘要】 目的 研究三維適形放射治療聯(lián)合多西他賽同期化療治療局部晚期非小細胞肺癌的療效和毒副作用。方法 63例局部晚期非小細胞肺癌患者隨機分成單放組和同期組。單放組30例采用序貫2周期TP方案化療及三維適形放射治療,總劑量66～70 Gy/33～35次, 6～7周完成。同期組33例采用三維適形放射治療同期化療(多西他賽+順鉑)。結果 兩組患者的總有效率分別為56. 7%和81. 8%,其中完全緩解率分別為6. 7%和27. 3%,差異有統(tǒng)計學意義(P<0. 05)。兩組1、2年生存率分別63.5%、79.4%和40.0%、54.5% (P>0.05)。單放組患者中位生存期為11.4個月, 同期組患者中位生存期為18.9個月。兩組患者早期放射反應主要為Ⅰ～Ⅱ級放射性食道炎和骨髓抑制,后期放射反應主要為Ⅰ～Ⅱ級放射性肺炎。結論 三維適形放射治療同期TP方案化療治療局部晚期非小細胞肺癌，與序貫放化療相比,可提高局部晚期非小細胞肺癌的近期療效,生存期也有提高的趨勢,但毒副反應有增加趨勢。

【關鍵詞】 非小細胞肺癌;三維適形放射治療;化學治療;多西他賽

An analysis of treatment effectiveness of three�瞕imensional conformal radiotherapy combined　with docetaxol in patients with locally advanced non�瞫mall cell lung cancerLI Chun�瞴ing, WEI Lin(Dept. of Radiotherapy, Taian City Central Hospital,Taian 271000, China)Abstract:Objective: To evaluate the therapeutic efficacy and the radiation complication of three�瞕imensional conformal radiotherapy (3DCRT) combined docetaxol in patients with locally advanced non�瞫mall cell lung cancer(NSCLC).Methods: 63 patients with locally advanced NSCLC were randomly divided into two groups. 30 patients in group A received 3DCRT at the total dose of 66 to 70 Gy in 33 to 35 fractions completed in 6 to 7 weeks. In the sequential chemoradiation group, two chemotherapy cycles were given before radiotherapy. 33 patients in group B received 3DCRT combined with Docetaxol. Results: The efficacy rates in group A and B were 56.7% and 81.8%, and the complete remission rates were 6.7% and 27.3% respectively. The differences were statistically significant (P<0.05). The 1 and 2- year survival rates of the patients in groupA and B were 63.5% VS 79.4%, 40.0%VS 54.5% respectively and there was no significant difference (P>0.05). The median survival time in group A and B were 11.4 months and 18. 9months respectively. The major radiation complication observed in the two groups were grade I to II acute radiation esophagitis and hematopoietic toxicity. The later radiation complication in the two groups were grade I to II radiation lung fibrosis. Conclusion: 3DCRT combined with Docetaxol is better in improving response and survival than sequential ones, but there is an ascendant tendency in adverse reaction醫(yī)學全.在線m.52667788.cn.

Key words:non�瞫mall cell lung cancer; three dimensional conformal radiotherapy; chemotherapy; docetaxol

肺癌已成為目前人類死亡的主要原因,不能手術的局部晚期非小細胞肺癌(non�瞫mall cell lung carcinoma, NSCLC)大約占肺癌的40%,單一治療生存率低,2年生存率僅為10%[1]。放射治療是治療局部晚期非小細胞肺癌患者的重要手段。近來多主張化療、放療綜合治療,以期延長生存期。根據(jù)局部晚期非小細胞肺癌的生物學行為和臨床特點,我科于2005年10月至2007年10月進行了三維適形放射治療聯(lián)合多西他賽+順鉑同期化療治療局部晚期非小細胞肺癌的臨床研究。結果報道如下。

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