主要研究方向: 本科是醫(yī)院特色專業(yè)的獨立科室,設立門診、骨密度檢測和骨質(zhì)疏松研究室,擁有最先進的雙能X線骨密度檢測儀3臺,臨床和實驗條件良好。目前主要研究方向為如下三部分:1、骨質(zhì)疏松的遺傳機制研究:迄今已經(jīng)分別建立男性、女性核心家系遺傳資源庫(800個家庭共近3000人的骨密度值和DNA),檢測骨質(zhì)疏松的易感基因,該領域研究水平居國內(nèi)領先;2、遺傳性代謝性骨病的分子機制研究;3、藥物遺傳學研究:分析抗骨質(zhì)疏松藥物療效與相關基因的關系。目前承擔國家自然科學基金:男性峰值骨量與骨代謝相關候選基因10個SNP的家系連鎖分析(30570891)。 主要研究成果: 第一作者發(fā)表學術論文近40篇,其中SCI收論文8篇。曾獲上海市醫(yī)學科技二等獎。發(fā)表主要論文: 1.Bone mineral density of the spine and femur in healthy Chinese men. Asian J Androl 2006; 8:419-427 (SCI收錄) 2.A20 overexpression under control of mouse osteocalcin promoter in MC3T3-E1 cells inhibited tumor necrosis factor-alpha-induced apoptosis. Acta Pharmacol Sin 2006; 27:1231-1237 (SCI收錄) 3.Association of polymorphisms in low-density lipoprotein receptor-related protein 5 gene with bone mineral density in postmenopausal Chinese women. Acta Pharmacol Sin 2005; 26: 1111-1116 (SCI收錄) 4.CMV-hFasL transgenic mice prevent from experimental autoimmune thyroiditis. Chin Med J 2005; 118 (13); 1087-1092(SCI收錄) 5.Association of estrogen receptor-alpha and vitamin D receptor genotypes with therapeutic response to calcium in postmenopausal Chinese women. Acta Pharmacol Sin 2004; 25: 1690-1697 (SCI收錄) 6.Xenotransplantaion of islet from Fas ligand transgenic mice in experimental diabetic rat. Transplantation Proceeding 2003; 35: 1508-1509 (SCI收錄) 7.Gene therapy of experimental autoimmune thyroiditis by in vivo administration of plasmid DNA coding for human interleukin-10. Acta Pharmacologica Sinica 2003; 24: 885-890 (SCI收錄) 8.Systemic delivery of interleukin 10 by intramuscular injection of expressing plasmid DNA prevents autoimmune diabetes. Acta Pharmacol Sin 2003; 24: 751-756 (SCI收錄) 9.骨質(zhì)疏松相關基因的研究方向。中華醫(yī)學雜志,2006;86:361-362 (專家評論) 10.細胞色素P450c 17α基因啟動子Msp AI多態(tài)性與上海市漢族男性骨量、骨大小的關系中國醫(yī)學科學院學報 2004;26: 687-691(論著) 11.雌激素受體-α基因Xba I、Pvu II和BstU I多態(tài)性與男性骨量的關系。中華醫(yī)學遺傳學雜志2005; 22: 451-453(論著) 12.Association of bone metabolism related genes polymorphisms with the effect of raloxifene hydrochloride on bone mineral density and bone turnover markers in postmenopausal women with osteoporosis. 中華醫(yī)學遺傳學雜志, 2006;23:129-133(論著) 13.維生素D受體基因啟始密碼子和CDX2多態(tài)性與鈣劑補充對絕經(jīng)后婦女骨密度作用的關系。中華醫(yī)學遺傳學雜志,2006;23:397-401(論著)