國(guó)家自然科學(xué)基金“DNA損傷應(yīng)激反應(yīng)中變異剪接基因的鑒定及其功能研究”No.30872140
負(fù)責(zé)人 m.52667788.cn￥320,000 2009.01 – 2011.12
科技部國(guó)際科技合作項(xiàng)目 “納米材料的生物安全性評(píng)估體系的建立” No. 2009DFB30390
負(fù)責(zé)人 ￥4,170,000 2008.09 – 2011.12
（丁秋萍 2009C11122)
發(fā)表文章:
1. Yang, J. and Duerksen-Hughes, P. (1998) A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis, 19, 1117-1125
2. Duerksen-Hughes, P., Yang, J., and Oczan, O. (1999) p53 induction as a genotoxic
test for twenty-five chemicals undergoing in vivo carcinogenicity testing. Env. Health
Persp., 107, 805-812
3. Duerksen-Hughes, P., Yang, J., and Schwartz, S. (1999) HPV 16 E6 blocks TNF-
mediated apoptosis in mouse fibroblast LM cells. Virology, 264, 55-65
4. Yang, J. and Duerksen-Hughes, P. (2001) Activation of a p53 independent, sphingolipid-mediated cytolytic pathway in p53-negative mouse fibroblast cells treated with N-methyl-N-nitro-N-nitrosoguanidine. J. Biol. Chem., 276, 27129-27135
5. Yang, J.*, Hooper, W. C., Phillips, D., and Talkington, D. (2002) Regulation of proinflammatory cytokines in human lung epithelial cells during Mycoplasma pneumoniae infection. Infect. Immun., 70, 3649-3655.
6. Yang, J., Hooper, W. C., Phillips, D., Tondella, M., and Talkington, D. (2002) Centrifugation of human lung epithelial carcinoma a549 cells up-regulates interleukin-1beta gene expression. Clin. Diagn. Lab. Immunol. 9, 1142-1143.
7. Yang, J., Hooper, W. C., Phillips, D., Tondella, M., and Talkington, D. (2003) Induction of proinflammatory cytokines in human lung epithelial cells during Chlamydia pneumoniae infection. Infect. Immun. 71, 614-620. 4.004
8. Yang, J., Hooper, W. C., Phillips, D., and Talkington, D. (2003) Interleukin-1beta responses to Mycoplasma pneumoniae infection are cell-type specific. Microbial Pathog., 34, 17-25. 2.258
9. Yang, J., Yu, Y., and Duerksen-Hughes, P. (2003) Protein kinases and their involvement in the cellular responses to genotoxic stress. Mutat. Res.-Rev. Mutat. Res., 543, 31-58. 7.579
10. Zhu, F., Jin, C., Song, T., Yang, J., Guo, L., Yu, Y. (2003) Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N’-nitro-N-nitrosoguanidine and its role in mutagenesis. World J. Gastroentol. 9, 888-893.
11. Jin, J., Gao, Z., Guo, L., Yang, J., and Yu, Y. (2003) Altered expression of zinc finger proteins, ADAMs, and integrin-related proteins following treatment of cultured human cells with a low concentration of N-methyl-N\'-nitro-N-nitrosoguanidine. Environ. Mol. Mutagen. 41, 344-352.
12. Wang, Z., Wang, G., Yang, J., Guo, L., and Yu, Y. (2003) Activation of Protein Kinase A and Clustering of Cell Surface Receptors by N-methyl-N\'-nitro-N-nitrosoguanidine are Independent of Genomic DNA damage. Mutat. Res. 528, 29-36. 4.111
13. Yang, J., Yu, Y., Hamrick, H. E., and Duerksen-Hughes, P. (2003) ATM, ATR, and DNA-PK: Initiators of cellular genotoxic stress response. Carcinogenesis, 24, 1571-1580. 5.366
